Help prevent fleas and ticks from pestering your pal with Frontline Plus Flea and Tick Large Breed Dog Treatment! This treatment is fast-acting, long-lasting and waterproof, and helps control these pesky pests on large-breed dogs and puppies eight weeks of age and older. The two tough pest control ingredients in this formula—fipronil and (S)-methoprene—work on killing adult fleas, eggs and larvae, helping to prevent against further infestations. Stored in the oil glands of your pal’s skin, it provides flea and tick prevention for a full 30 days. No more bugs bugging your pup!